O5 PGS by polar body biopsy – High aneuploidy rate independent of age
نویسندگان
چکیده
منابع مشابه
What next for preimplantation genetic screening (PGS)? Experience with blastocyst biopsy and testing for aneuploidy.
Blastocysts more commonly have a normal karyotype than cleavage-stage embryos do. Moreover, blastocysts have also made a metabolic transition from catabolism and recycling of the oocyte's reserves and resources, processes that fuel the first 3 days of cleavage. Although not all blastocysts are karyotypically equal, it is still to be determined to what extent a mosaic karyotype might be a normal...
متن کاملESHRE PGD Consortium/Embryology Special Interest Group--best practice guidelines for polar body and embryo biopsy for preimplantation genetic diagnosis/screening (PGD/PGS).
In 2005, the European Society for Human Reproduction and Embryology (ESHRE) Preimplantation Genetic Diagnosis (PGD) Consortium published a set of Guidelines for Best Practice to give information, support and guidance to potential, existing and fledgling PGD programmes (Thornhill AR, De Die-Smulders CE, Geraedts JP, Harper JC, Harton GL, Lavery SA, Moutou C, Robinson MD, Schmutzler AG, Scriven P...
متن کاملESHRE PAGES ESHRE PGD Consortium/Embryology Special Interest Group—best practice guidelines for polar body and embryo biopsy for preimplantation genetic diagnosis/screening (PGD/PGS)
In 2005, the European Society for Human Reproduction and Embryology (ESHRE) Preimplantation Genetic Diagnosis (PGD) Consortium published a set of Guidelines for Best Practice to give information, support and guidance to potential, existing and fledgling PGD programmes (Thornhill AR, De Die-Smulders CE, Geraedts JP, Harper JC, Harton GL, Lavery SA, Moutou C, Robinson MD, Schmutzler AG, Scriven P...
متن کاملIndependent assessment of source transit time for the BEBIG SagiNova® high dose rate brachytherapy afterloader
Introduction: The dwell time and transit time components contribute to the overall delivered dose to patients in high dose rate (HDR) brachytherapy treatments. The transit time results from source entry and exit as well as source movements between dwell positions. It depends on various parameters such as the source speed profile, source indexer distance to dwell position, and ...
متن کاملI-35: Polar Body Analysis by Array CGH Identifies Women with Varying Susceptibility to Aneuploidy and Suggests that Non-disjunction Is Not The Predominant Mechanism Leading to Aneuploidy in Humans
Background: The maternal age effect for trisomy is well known. However what is less established is whether certain women are more (or less) prone to segregation errors, independent of age. Trisomy arises primarily through maternal meiosis I chromosome segregation errors however the precise mechanism by which these errors occur is unclear. Current dogma attributes the origin of trisomy to malseg...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2010
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)62302-4